全文总结本研究系统揭示了运动改善阿尔茨海默病认知障碍的肌 - 脑通讯机制：游泳运动诱导骨骼肌分泌富含 miR-378a-3p 的细胞外囊泡，该囊泡穿越血脑屏障后被小胶质细胞摄取，通过靶向 p110α 调控脂质代谢重编程，激活疾病相关小胶质细胞的淀粉样蛋白斑块清除功能，最终改善认知障碍。同时证实，过表达 miR-378a-3p 的肌管来源囊泡可模拟运动的治疗效果，为阿尔茨海默病提供了全新的运动模拟型靶向治疗策略，也为理解外周组织与中枢神经系统的通讯提供了新视角。
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With a plain old LED panel, the Vizio isn't going to turn any heads or impress your most keen-eyed friends, but it's more than good enough for a night in catching up on your stories. It still has full support for Dolby Vision, plus HDR10+ for all your high dynamic range needs. It even has some gaming chops, with 60Hz at 4K, or 120Hz at 1080p with motion enhancement turned on, good enough for all but the newest consoles and gaming computers. If your device supports it, the Vizion has Variable Refresh Rate (VRR) to match the screen's current refresh rate to the FPS of your game to reduce tearing.
第十三条 国家建立原子能领域相关科技创新基地和平台，加强原子能科研设施和科研条件保障能力建设，推动科研设施、资源开放共享，促进科技成果转化。